INVESTIGATION OF NEW COMMERCIAL SODIUM STARCH GLYCOLATE PRODUCTS

The availability of 4 experimental sodium starch glycolates (SSG) was investigated. The effects of the molecular structure (degree of substi tution) and of the purity (sodium chloride content) on the disintegrat ion efficiency and on the dissolution rate were also studied. A higher degree of substitution and lower sodium chloride content resulted in a shorter disintegration time and faster dissolution. The new experime ntal SSG products appeared to be excellent disintegrants. They are as good as Primojel(R) or Explotab(R). They were effective in a concentra tion as low as 2.6 % in the case of hydrophobic nondisintegrating phen ylbutazone tablets prepared by wet granulation.