The authors assessed bone mineral density in androgenized amenorrheic
(group A; n = 9) and androgenized nonamenorrheic patients (group B; n
= 30) and compared it with controls (n = 22). Bone mineral density of
group A patients (1.023 +/- 0.045 g/cm2) did not differ from controls
(1.047 +/- 0.83 g/cm2); both groups had significantly lower values tha
n group B women (1.099 +/- 0.085 g/cm2). Of the hormonal variables exp
laining bone mineral density in androgenized women, only dehydroepiand
rosterone sulfate had a significant negative correlation (r = -0.45).
In contrast to other forms of amenorrhea, women with hyperandrogenic a
menorrhea seem to be spared from osteopenia.