ALCOHOL EXPOSURE BEFORE PREGNANCY - EFFECT ON GABA LEVELS AND TURNOVER IN RAT OFFSPRING

Authors
LEDIG M SIMLER S CIESIELSKI L MANDEL P
Citation
M. Ledig et al., ALCOHOL EXPOSURE BEFORE PREGNANCY - EFFECT ON GABA LEVELS AND TURNOVER IN RAT OFFSPRING, Alcohol and alcoholism, 28(2), 1993, pp. 175-179
Citations number
32
Categorie Soggetti
Substance Abuse
Journal title
Alcohol and alcoholism → ACNP
ISSN journal
07350414
Volume
28
Issue
2
Year of publication
1993
Pages
175 - 179
Database
ISI
SICI code
0735-0414(1993)28:2<175:AEBP-E>2.0.ZU;2-6
Abstract
The GABA levels and turnover rates in various brain areas from 2-month -old rats born to mothers who consumed 20% (v/v) alcohol during 1 mont h only before pregnancy, were investigated. A decreased level was foun d in the olfactory tubercules and an increase was observed in the hypo thalamus. The turnover rates were reduced in both areas, whereas an in crease was observed in the frontal cortex. These results indicate that biochemical alterations may occur in the offspring even if the fetus did not develop under alcoholization.