T. Hofstad et al., STIMULATION OF B-LYMPHOCYTES BY LIPOPOLYSACCHARIDES FROM ANAEROBIC-BACTERIA, Clinical infectious diseases, 16, 1993, pp. 190000200-190000202
Lipopolysaccharides (LPSs) from anaerobic gram-negative bacteria, incl
uding those of low endotoxic activity that are isolated from Bacteroid
es, Prevotella, and Porphyromonas are potent inducers of DNA replicati
on and polyclonal immunoglobulin production in murine B lymphocytes. T
he activation is dose-dependent and T cell-independent. Replication of
DNA and production of immunoglobulins were also stimulated by lipid A
and by the LPS heteropolysaccharide that were isolated by mild acid h
ydrolysis of the LPSs of Bacteroides fragilis and Fusobacterium nuclea
tum. Combinations of LPS, lipid A, and acid-degraded polysaccharide am
plified the blastogenic response. Antibodies that react with the polys
accharide part of LPSs isolated from members of the Bacteroidaceae are
present in healthy human serum.