Tj. Anderson et al., SINOATRIAL AND ATRIOVENTRICULAR-BLOCK CAUSED BY INTRACORONARY INFUSION OF ADENOSINE EARLY AFTER HEART-TRANSPLANTATION, The Journal of heart and lung transplantation, 12(3), 1993, pp. 522-524
Intracoronary adenosine was infused in 22 patients early (less than 2
months) after heart transplantation to study coronary flow reserve in
the left anterior descending artery. Potentially serious bradycardia r
equiring discontinuation of the infusion occurred in three patients. T
his complication had not been noted when adenosine was given to 84 pat
ients at least 1 year after transplantation. Newly transplanted hearts
may therefore have increased susceptibility to the bradycardic action
of adenosine, which should be used with caution in this population.