The factorial design is used to study interferences of [K+] and pH dur
ing ammonium determination by NH4 - ISE. It is concluded that as resul
t of a negative pH-[K+] interactive interference the positive interfer
ence of [K+] may be diminished. The optimal pH for NH4+ determination
is 7.4. A complete procedure is presented to diminish the interference
s of [K+] and pH. Parallelly an indirect method is used for the determ
ination of total ammonium in urine.