CHOLECYSTOKININ AND SATIATION

Peripheral signals from stomach and small intestine are believed to in duce satiation. In experimental animals, satiation factors can be tran sfused pointing to the humoral nature of the signal. Cholecystokinin ( CCK) may be an important mediator, since infusion of exogenous CCK has been demonstrated to induce satiation and to inhibit gastric emptying . However, whether this effect of CCK is a physiological or pharmacolo gical event is a matter of controversy. The significance of exogenous CCK or stimulation of endogenous CCK in the possible treatment of obes ity requires further study.