SINGLE BONE METASTASIS AS INITIAL MANIFES TATION OF AN UNDIFFERENTIATED VESICAL CARCINOMA

The spread of Vesical Neoplasia occurs frequently through local or reg ional extension. Its systemic dissemination happens frequently in adva nced phases but it is exceptional as initial manifestation. The case o f an undifferentiated vesical carcinoma is described, its presentation was as a big size osteolytic lesion on the sacrum. Local manifestatio ns of the tumor appeared later. The study performed both in bones as w ell as in the vesical mucosa showed an undifferentiated adenocarcinoma . The great resemblance and histological and immunohistochemical conco rdances of both biopsies confirmed that it was a primary vesical neopl asia with a metastasis in sacrum. The specific clinical evolution of t his tumor is discussed which is probably related with the fact that it is an undifferentiated carcinoma.