Threshold retinopathy of prematurity is a level of disease at which 50
% of affected infants are predicted to go blind without treatment. The
Cryotherapy for Retinopathy of Prematurity Study has shown that this
number can be halved with treatment. Cryotherapy, however, is stressfu
l on the infant, leaves large scars, and is more difficult for the sur
geon to administer. Laser photocoagulation with the indirect ophthalmo
scope has been shown in pilot studies to be as effective as cryotherap
y, less stressful on the infant, and easier for the surgeon to adminis
ter. This form of therapy may become the preferred method for treating
threshold retinopathy of prematurity.