We report our experience with closure of the bladder during laparoscop
ic nephroureterectomy by using a gastrointestinal anastomosis type sta
pling device designed to deliver 6, 3 cm. rows of 3.5 mm. titanium sta
ples via a 12 mm. trocar. We initially used this stapling device to se
cure a cuff of bladder in 8 female pigs undergoing laparoscopic nephro
ureterectomy. Followup in these animals was completed 2 to 6 months po
stoperatively. Then, 3 patients underwent laparoscopic ureterectomy us
ing the laparoscopic stapler to transect and secure the ureter along w
ith a cuff of bladder. In neither the laboratory nor the clinical situ
ation were any complications encountered due to the transvesical stapl
es (for example extravasation, stone formation, urinary tract infectio
n or abscess formation). Our preliminary results indicate that titaniu
m staples may be an effective method to provide rapid and secure closu
re of the bladder in patients undergoing either laparoscopic nephroure
terectomy or laparoscopic ureterectomy.