We report benign retroperitoneal fibrosis associated with renal cell c
arcinoma in a 56-year-old woman. Based on the preoperative evaluation
and initial surgical exploration, the retroperitoneal mass was assumed
to be metastatic renal cell carcinoma and chemotherapy rather than su
rgical resection was offered to the patient. A second opinion was soug
ht and repeat exploration revealed a resectable renal cell carcinoma a
nd retroperitoneal tissue that was pathologically benign idiopathic re
troperitoneal fibrosis. This report emphasizes that a patient with an
otherwise resectable primary tumor must undergo multiple, deep biopsie
s of retroperitoneal masses before making a presumptive diagnosis of m
alignant retroperitoneal fibrosis secondary to metastatic cancer.