ACROMEGALY WITH POLYCYSTIC OVARIES, HYPERANDROGENISM, HIRSUTISM, INSULIN RESISTANCE AND ACANTHOSIS NIGRICANS - A CASE-REPORT

We describe a woman with acromegaly who had acanthosis nigricans and h irsutism. Serum growth hormone (GH) and testosterone levels were marke dly elevated. Standard oral glucose tolerance test (OGTT) showed a dia betic curve and no suppressed GH levels. Fasting insulin levels were v ery high while plasma glucose levels were not hypoglycemic. Insulin to lerance test revealed blunted hypoglycemic response. Acanthosis nigric ans was present in the right axilla and face. Ultrasonogram demonstrat ed bilateral polycystic changes in the ovaries. From the above finding s this patient's condition is characteristic of a very rare syndrome c onsisting of acromegaly, polycystic ovaries (PCO), hyperandrogenism, h irsutism, insulin resistance and acanthosis nigricans.