THE SEQUENCE OF 5'-FLANKING DNA FROM THE MOUSE 11-BETA-HYDROXYSTEROIDDEHYDROGENASE TYPE-1 GENE AND ANALYSIS OF PUTATIVE TRANSCRIPTION FACTOR-BINDING SITES

Authors
VOICE MW SECKL JR CHAPMAN KE
Citation
Mw. Voice et al., THE SEQUENCE OF 5'-FLANKING DNA FROM THE MOUSE 11-BETA-HYDROXYSTEROIDDEHYDROGENASE TYPE-1 GENE AND ANALYSIS OF PUTATIVE TRANSCRIPTION FACTOR-BINDING SITES, Gene, 181(1-2), 1996, pp. 233-235
Citations number
25
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
181
Issue
1-2
Year of publication
1996
Pages
233 - 235
Database
ISI
SICI code
0378-1119(1996)181:1-2<233:TSO5DF>2.0.ZU;2-4
Abstract
11 beta-Hydroxysteroid dehydrogenase type 1 (E.C. 1.1.1.146) (11 beta- HSD 1) is a key enzyme in the metabolism of glucocorticoids, catalysin g their interconversion with physiologically inert 11-keto metabolites . To identify transcription factors which may be involved in the regul ation of expression of mouse 11 beta-HSD 1 we have isolated and sequen ced the 5' flanking DNA to 900 bp upstream from the major transcriptio n start site.