THE EFFECT OF INTRAVENOUS OMEPRAZOLE ON THE GASTRIC AND DUODENAL POTENTIAL DIFFERENCE AND PH IN HEALTHY-SUBJECTS

Authors
RUBINSTEIN E HOJGAARD L
Citation
E. Rubinstein et L. Hojgaard, THE EFFECT OF INTRAVENOUS OMEPRAZOLE ON THE GASTRIC AND DUODENAL POTENTIAL DIFFERENCE AND PH IN HEALTHY-SUBJECTS, Digestion, 54(1), 1993, pp. 15-18
Citations number
17
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Digestion → ACNP
ISSN journal
00122823
Volume
54
Issue
1
Year of publication
1993
Pages
15 - 18
Database
ISI
SICI code
0012-2823(1993)54:1<15:TEOIOO>2.0.ZU;2-2
Abstract
The effect of intravenous omeprazole (40 and 80 mg) on the gastric and duodenal potential difference (PD) and pH was investigated in 9 healt hy volunteers. Gastric PD and pH increased significantly (p < 0.05) fo llowing omeprazole, and the increases were equal following the two dos es. No changes were found in duodenal PD or pH. It has been claimed th at gastric PD changes following acid secretion inhibition with cimetid ine and glucagon might be due to changes in the parietal cell surface area. Omeprazole causes no changes in the parietal cell structure, and the changes in gastric PD following omeprazole might therefore be asc ribed to changes in mucosal electrophysiologic transport or resistance .