EXPRESSION OF THE ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULE-1 (ELAM-1) ON ENDOTHELIAL-CELLS IN EXPERIMENTAL GINGIVITIS IN HUMANS

IN INFLAMMATORY CONDITIONS, MEDIATORS such as interleukin-1 (IL-1) are released by resident tissue cells as well as by infiltrating inflamma tory cells. IL-1 activates endothelial cells causing them to express a n adhesion molecule called endothelial leukocyte adhesion molecule-1 ( ELAM-1). IL-1 is produced by macrophages, but can also be produced by activated keratinocytes. Here we present data from a study of experime ntally induced gingivitis, showing the expression of ELAM-1 on endothe lial cells even in tissue with little or only minor signs of clinical or histological inflammation. These results indicate that ELAM-1 is fo und on endothelial cells of the gingiva early in the course of experim ental gingivitis, before overt clinical or histological evidence of in flammation is apparent.