K. Nylander et al., EXPRESSION OF THE ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULE-1 (ELAM-1) ON ENDOTHELIAL-CELLS IN EXPERIMENTAL GINGIVITIS IN HUMANS, Journal of periodontology, 64(5), 1993, pp. 355-357
IN INFLAMMATORY CONDITIONS, MEDIATORS such as interleukin-1 (IL-1) are
released by resident tissue cells as well as by infiltrating inflamma
tory cells. IL-1 activates endothelial cells causing them to express a
n adhesion molecule called endothelial leukocyte adhesion molecule-1 (
ELAM-1). IL-1 is produced by macrophages, but can also be produced by
activated keratinocytes. Here we present data from a study of experime
ntally induced gingivitis, showing the expression of ELAM-1 on endothe
lial cells even in tissue with little or only minor signs of clinical
or histological inflammation. These results indicate that ELAM-1 is fo
und on endothelial cells of the gingiva early in the course of experim
ental gingivitis, before overt clinical or histological evidence of in
flammation is apparent.