LOCALIZATION OF THE HUMAN CD59 GENE BY FLUORESCENCE INSITU HYBRIDIZATION AND PULSED-FIELD GEL-ELECTROPHORESIS

Authors
HECKLOSTREICHER B RAGG S DRECHSLER M SCHERTHAN H ROYERPOKORA B
Citation
B. Hecklostreicher et al., LOCALIZATION OF THE HUMAN CD59 GENE BY FLUORESCENCE INSITU HYBRIDIZATION AND PULSED-FIELD GEL-ELECTROPHORESIS, Cytogenetics and cell genetics, 63(3), 1993, pp. 144
Citations number
20
Categorie Soggetti
Cytology & Histology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
63
Issue
3
Year of publication
1993
Database
ISI
SICI code
0301-0171(1993)63:3<144:LOTHCG>2.0.ZU;2-6
Abstract
We have localized the human CD59 gene encoding a membrane protein that inhibits cell lysis by the membrane-attack complex of the homologous complement system. Using chromosomal in situ suppression hybridization and pulsed-field gel electrophoresis, we mapped this gene to chromoso me 11p13, distal to the breakpoint of acute T-cell leukemia and proxim al to the locus of the Wilms' tumor gene on a 30-kb SacII fragment.