APPLICATION OF ORTHOGONAL FUNCTIONS TO SPECTROPHOTOMETRIC ANALYSIS - DETERMINATION OF DISSOCIATION-CONSTANTS

Authors
WAHBI AM ELYAZBI FA BARARY MH SABRI SM
Citation
Am. Wahbi et al., APPLICATION OF ORTHOGONAL FUNCTIONS TO SPECTROPHOTOMETRIC ANALYSIS - DETERMINATION OF DISSOCIATION-CONSTANTS, International journal of pharmaceutics, 92(1-3), 1993, pp. 15-21
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
92
Issue
1-3
Year of publication
1993
Pages
15 - 21
Database
ISI
SICI code
0378-5173(1993)92:1-3<15:AOOFTS>2.0.ZU;2-0
Abstract
Glenn's method of orthogonal functions (J. Pharm. Pharmacol., 15 (1963 ) 123T-130T) is extended to the spectrophotometric determination of di ssociation constants of some weakly acidic and basic drugs. The calcul ated comparative coefficients, Q(j), of the dissociated, undissociated and partially dissociated forms of the drug have been used to calcula te the pK(a) values. A graphical technique based upon plotting orthogo nal function titration curves is also presented. The results obtained are in good agreement with the reported values.