DEVELOPMENT OF POLY (DIALKYL METHYLIDENEMALONATE) NANOPARTICLES AS DRUG CARRIERS

Authors
MBELA TKM POUPAERT JH DUMONT P HAEMERS A
Citation
Tkm. Mbela et al., DEVELOPMENT OF POLY (DIALKYL METHYLIDENEMALONATE) NANOPARTICLES AS DRUG CARRIERS, International journal of pharmaceutics, 92(1-3), 1993, pp. 71-79
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
92
Issue
1-3
Year of publication
1993
Pages
71 - 79
Database
ISI
SICI code
0378-5173(1993)92:1-3<71:DOP(MN>2.0.ZU;2-F
Abstract
Two novel dialkylmethylidenemalonate (DAMM) analogs: diallylmethyliden emalonate (AAMM, 1b) and cyclohexylethylmethylidenemalonate (CEMM, 1c) were synthesized and evaluated for their capacity to polymerise to st able nanoparticles and to adsorb primaquine diphosphate (PQ). PQ loadi ng onto poly-AAMM (PAAMM, 1b) and poly-CEMM (PCEMM, 1c) was up to 90% in the pH range from 6.0 to 8.5. A significant improvement of the phys icochemical characteristics and the PQ desorption capacity of the nano particles was achieved in this series of PDAMM analogs.