A. Demanuele et Jn. Staniforth, EFFECTS OF POLYMER FORMULATION ON ELECTROPHORETIC DRUG DELIVERY, International journal of pharmaceutics, 92(1-3), 1993, pp. 225-231
A controlled drug delivery device based on the principle of electropho
resis is described in this paper. A model system using propranolol HCl
and PHEMA films is used to demonstrate how control over the release o
f a model drug may be achieved using low constant electric currents. P
olymer formulation is shown to be important, highly crosslinked polyme
r producing a different effect to low crosslinked polymer. The model i
s used to demonstrate the low power requirements for control over drug
transport and indicates the feasibility of using an electrophoretical
ly controlled drug delivery device to provide truly controllable and p
redictable release rates.