INVESTIGATIONS OF THE CORRELATION BETWEEN BACTERIAL UPTAKES OF TRIMETHOPRIM AND SULFADIAZINE WITH ANTIBACTERIAL ACTIVITIES AGAINST ENTEROCOCCUS-FAECALIS

Authors
RICHARDS RME TAYLOR RB XING JZ
Citation
Rme. Richards et al., INVESTIGATIONS OF THE CORRELATION BETWEEN BACTERIAL UPTAKES OF TRIMETHOPRIM AND SULFADIAZINE WITH ANTIBACTERIAL ACTIVITIES AGAINST ENTEROCOCCUS-FAECALIS, International journal of pharmaceutics, 92(1-3), 1993, pp. 237-241
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
92
Issue
1-3
Year of publication
1993
Pages
237 - 241
Database
ISI
SICI code
0378-5173(1993)92:1-3<237:IOTCBB>2.0.ZU;2-P
Abstract
Bacterial uptake determinations were performed to evaluate the antibac terial effects of trimethoprim, sodium sulphadiazine and dibromopropam idine isethionate against Enterococcus faecalis together with checkerb oard assays and agar diffusion determinations. The reciprocal effects of trimethoprim (17.5 mug/ml) and sodium sulphadiazine (100 mug/ml) ag ainst E. faecalis culture produced cell uptakes of 14-times the concen tration of sodium sulphadiazine and 5-times the concentration of trime thoprim. Folinic acid partially reversed the bacterial uptakes.