NEONATAL HERPES-SIMPLEX VIRUS-INFECTION

The incidence of genital herpes simplex virus (HSV) and neonatal HSV i nfection is increasing in the United States. The risk to the neonate o f a woman with genital recurrences (1%-3%) versus first-episode infect ion (30%-50%), even when asymptomatic, has been defined. Appreciation of the subtle clinical signs, as well as more obvious cutaneous signs of neonatal infection, will lead to appropriate diagnostic evaluation (including, at times, polymer ase chain-reaction assay) and therapy. U nderstanding the immune defects predisposing the neonate to severe HSV infection will enhance efforts to reconstitute the neonate's immune f unction. Maternal vaccination, chemoprophylaxis, and appropriate use o f cesarean-section delivery may prevent cases of neonatal herpes now a nd in the future.