IMMUNOSUPPRESSIVE ACTION OF CYCLOPHOSPHAMIDE IN MICE - CONTRIBUTION OF SOME FACTORS TO DETERMINATION OF STRAIN DIFFERENCES

Authors
PUKHALSKY AL TOPTYGINA AP VIKTOROV VV
Citation
Al. Pukhalsky et al., IMMUNOSUPPRESSIVE ACTION OF CYCLOPHOSPHAMIDE IN MICE - CONTRIBUTION OF SOME FACTORS TO DETERMINATION OF STRAIN DIFFERENCES, International journal of immunopharmacology, 15(4), 1993, pp. 509-514
Citations number
13
Categorie Soggetti
Immunology,"Pharmacology & Pharmacy
Journal title
International journal of immunopharmacology → ACNP
ISSN journal
01920561
Volume
15
Issue
4
Year of publication
1993
Pages
509 - 514
Database
ISI
SICI code
0192-0561(1993)15:4<509:IAOCIM>2.0.ZU;2-I
Abstract
Mechanisms of strain differences in susceptibility to cyclophosphamide (CP) has been investigated with BALB/c, DBA/2, CC57BR, and C57BL/6 mi ce. It was shown that the final immunosuppressive effects of CP is a r esult of a combination of such factors as the level of CP alkylating m etabolites in the bloodstream and the sensitivity of the target cells to antiproliferative action of these metabolites. The importance of th e immune status peculiarities has been discussed.