CHRONIC DEMYELINATING NEUROPATHY AND INTRAAXONAL POLYGLUCOSAN BODIES

In this study we evaluated the relationship between polyglucosan bodie s and peripheral nerve lesions. The biopsied sural nerve from a patien t with late-onset chronic sensori-motor neuropathy showed many intra-a xonal polyglucosan bodies and segmental demyelination/remyelination. T he formation of Schwann cell hyperplasia around the demyelinated axons was found at the sites of polyglucosan bodies. These findings suggest that demyelinating neuropathy is a part of the spectrum of the diseas es characterized by the accumulation of polyglucosan bodies within cel lular compartments.