STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .6. SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF 4,5-DIHYDRO-S-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINES

Authors
AMBROGI V GRANDOLINI G PERIOLI L GIAMPIETRI A
Citation
V. Ambrogi et al., STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .6. SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF 4,5-DIHYDRO-S-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINES, Il Farmaco, 48(5), 1993, pp. 653-664
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
5
Year of publication
1993
Pages
653 - 664
Database
ISI
SICI code
0014-827X(1993)48:5<653:SOA1A1>2.0.ZU;2-A
Abstract
A series of new 1-alkylaminomethyl derivatives of 4,5-dihydro-s-triazo le[3,4-d]-1,5-benzothiazepines has been prepared using chloromethyltri azolobenzothiazepines 4a-g as key intermediates. - The 1-alkylaminomet hyl derivatives were tested for CNS activity on mice and some of them caused remarkable decrease of spontaneous motor activity