PROTEIN-LOSING ENTEROPATHY AND HYPOALBUMINEMIA IN AIDS

Objective: To assess the contribution of protein-losing enteropathy to AIDS-associated hypoalbuminemia. Design: Prospective assessment of pa tients with AIDS. Setting. An urban county hospital (Los Angeles & Uni versity of Southern California Medical Center. USA). Patients: Four gr oups of patients with AIDS were studied: (1) patients with normal seru m albumin (greater-than-or-equal-to 3.9 g/dl) and normal bowel habits; (2) patients with normal serum albumin and diarrhea (greater-than-or- equal-to four loose or watery stools per day for greater-than-or-equal -to 2 weeks); (3) patients with hypoalbuminemia (less-than-or-equal-to 3.0 g/dl) and normal bowel habits; and (4) patients with hypoalbumine mia and diarrhea. Main outcome measure: Fecal alpha1-antitrypsin conce ntration was used as a measure of protein loss in the gut. Results: Pa tients with hypoalbuminemia had a significantly higher mean fecal alph a1-antitrypsin concentration than those with normal albumin (10.8 +/- 3.0 mg/g dry stool versus 2.4 +/- 0.4 mg/g dry stool; P less-than-or-e qual-to 0.001). Although mean fecal alpha1-antitrypsin concentrations were similar in patients with and without diarrhea in the normal album in group, patients with hypoalbuminemia and diarrhea had signficantly higher levels of fecal alpha1-antitrypsin than those with hypoalbumine mia and normal bowel habits (17.3 +/- 5.8 mg/g dry stool versus 4.6 +/ - 1.0 mg/g dry stool; P = 0.009). Twelve out of 36 (33%) patients with normal albumin had elevation of fecal alpha1-antitrypsin compared wit h 33 (70%) of 47 patients with hypoalbuminemia (P less-than-or-equal-t o 0.001). Linear regression analysis showed a significant negative cor relation between serum albumin and fecal alpha1-antitrypsin concentrat ion (r = -0.38; P less-than-or-equal-to 0.001). Fecal alpha1-antitryps in was significantly higher in patients with mucosal disease visualize d at upper endoscopy or flexible sigmoidoscopy than in those without g ross abnormalities (13.5 +/- 5.8 mg/g dry stool versus 2.4 +/- 0.7 mg/ g dry stool; P = 0.005). Conclusion: Protein-losing enteropathy is com mon in patients with AIDS and may contribute to the development of hyp oalbuminemia in these patients.