The aims of this study were to assess the prevalence of HIV-1 infectio
n among a group of transvestite prostitutes in Rio de Janeiro and to i
dentify HIV-related risk behaviors to develop targeted intervention st
rategies. A total of 46 transvestite sex workers were recruited and as
sessed regarding drug use and sexual risk behaviors. Sixty-three perce
nt tested positive for antibody to HIV-1. Injection drug use was the o
nly factor statistically related to HIV seropositivity. However, sexua
l risk behaviors, including unprotected anal sex and sex for drug exch
anges, were reported by a substantial part of the sample. In addition,
given that they engage in both receptive and insertive anal sex with
a primarily heterosexual male clientele, they may be playing a role in
the heterosexual spread of HIV/AIDS in Brazil. The results of this st
udy suggest that transvestite sex workers are at uniquely high risk fo
r HIV infection and that intervention efforts for this population must
be equally unique.