ENHANCEMENT BY TAMOXIFEN OF THE MEMBRANE ANTIOXIDANT ACTION OF THE YEAST MEMBRANE STEROL ERGOSTEROL - RELEVANCE TO THE ANTIYEAST AND ANTICANCER ACTION OF TAMOXIFEN
H. Wiseman et al., ENHANCEMENT BY TAMOXIFEN OF THE MEMBRANE ANTIOXIDANT ACTION OF THE YEAST MEMBRANE STEROL ERGOSTEROL - RELEVANCE TO THE ANTIYEAST AND ANTICANCER ACTION OF TAMOXIFEN, Biochimica et biophysica acta, 1181(3), 1993, pp. 201-206
The anticancer drug tamoxifen inhibits lipid peroxidation in ox-brain
phospholipid liposomes, and is a good antiyeast agent, with clinical p
otential. We now report that the ergosterol-containing lipid fraction
derived from yeast microsomal membranes (and the ergosterol separated
from it) inhibited lipid peroxidation when introduced into ox-brain ph
ospholipid liposomes. Inhibition of lipid peroxidation by the lipid fr
action was greatly enhanced when yeast cell growth was inhibited with
tamoxifen prior to lipid extraction. The ability of tamoxifen to enhan
ce the membrane antioxidant ability of ergosterol is expressed in term
s of a tamoxifen enhancement coefficient. Enhancement by tamoxifen of
the membrane antioxidant action of ergosterol is discussed in relation
to the antifungal and anticancer actions of tamoxifen.