M. Ayubayala et al., EFFECT OF SHORT-TERM CARBON-TETRACHLORIDE ADMINISTRATION ON BLOOD LACTIC-ACID LEVELS, General pharmacology, 24(3), 1993, pp. 627-630
1. A short-term CCl4 administration was used in vivo as a model to pro
duce a rise in lactic acid levels and to explain the probable interact
ion of CCl4 and lactic acid elevation with hepatic fibrogenesis. 2. A
single dose of CCl4 produced an increase in lactic acid levels from 16
.6 +/- 3.57 to 24.2 +/- 4.2 mg/dl. Three consecutive doses produced an
elevation to 33.28 +/- 10.07 mg/dl, thus describing a direct relation
ship between lactic acid levels and CCl4 administration in a short-ter
m fashion. 3. A morphological evaluation was performed to show hepatic
changes caused by CCl4 administration. No clue of fibrogenesis was fo
und. However, we conclude that an elevation in lactic acid exists, pri
or to cirrhosis. Therefore, chronic presence of lactic acid may lead t
o cirrhosis.