INFLUENCE OF (-)-S-BAY K-8644, (+ -)-BAY W-5035 AND (+/-)-BAY T-5006 ON HEMODYNAMICS AND FITC-DEXTRAN 3 ELUTION KINETICS IN ISOLATED RAT HEARTS/

Authors
RUMP AFE RATKE R FRICKE U KLAUS W
Citation
Afe. Rump et al., INFLUENCE OF (-)-S-BAY K-8644, (+ -)-BAY W-5035 AND (+/-)-BAY T-5006 ON HEMODYNAMICS AND FITC-DEXTRAN 3 ELUTION KINETICS IN ISOLATED RAT HEARTS/, General pharmacology, 24(3), 1993, pp. 631-636
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
24
Issue
3
Year of publication
1993
Pages
631 - 636
Database
ISI
SICI code
0306-3623(1993)24:3<631:IO(K(->2.0.ZU;2-G
Abstract
1. We investigated the effects of the new calcium-agonists (+/-)-Bay W 5035 and (+/-)-Bay T 5006 in comparison to (-)-S-Bay K 8644 on hemody namics and epimyocardial perfusion in Langendorff rat hearts. 2. At eq uieffective inotropic concentration, vasoconstriction of coronary resi stance vessels was significantly less after (+/-)-Bay W 5035 or (+/-)- Bay T 5006 than after (-)-S-Bay K 8644 application. 3. FITC-Dextran 3 elution kinetics indicated that the epimyocardial vascular volume was significantly reduced only by (-)-S-Bay K 8644. 4. Moreover, (-)-S-Bay K 8644 enhanced transcoronary exchange more markedly than (+/-)-Bay W 5035 or (+/-)-Bay T 5006, reflecting the differences in coronary cons trictor activity. 5. We conclude that in comparison to (-)-S-Bay K 864 4 the relation between inotropy and vasoconstriction is more favorable for (+/-)-Bay W 5035 or (+/-)-Bay T 5006.