KETOROLAC TROMETHAMINE - AN EXPERIMENTAL-STUDY OF ITS ANALGESIC EFFECTS IN THE RAT

1. The formalin test and R-III nociceptive electromyographic reflex we re used to determine the origin of analgesia induced by ketorolac trom ethamine (KT) in rats. 2. The effects of KT and morphine were compared after i.v. administration. 3. Mepacrine and indomethacin were associa ted to KT to determine if prostaglandins are involved in the central a ction of KT. 4. In both tests KT had a poor analgesic effect without d ose-response relationships. 5. A central component is involved in the analgesia produced by KT, but neither prostaglandins nor opioid recept ors seem to mediate this effect.