LIQUID-CHROMATOGRAPHIC STUDY OF THE STABILITY OF 5-HALOGENO-2'-DEOXYURIDINES

Authors
VANSCHEPDAEL A OSSEMBE N HERDEWIJN P ROETS E HOOGMARTENS J
Citation
A. Vanschepdael et al., LIQUID-CHROMATOGRAPHIC STUDY OF THE STABILITY OF 5-HALOGENO-2'-DEOXYURIDINES, Journal of pharmaceutical and biomedical analysis, 11(4-5), 1993, pp. 345-351
Citations number
33
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
11
Issue
4-5
Year of publication
1993
Pages
345 - 351
Database
ISI
SICI code
0731-7085(1993)11:4-5<345:LSOTSO>2.0.ZU;2-3
Abstract
The stability of a series of 5-halogeno-2'-deoxyuridines was investiga ted using liquid chromatography as the analytical technique. Character istics and profiles of the acidic, neutral and alkaline degradation ar e described, together with Arrhenius relationships and activation para meters for weakly acidic media.