IMMEDIATE DECLINE IN DNA-SYNTHESIS IN NEONATAL RAT LUNG CAUSED BY EXPOSURE TO 100-PERCENT OXYGEN

Authors
WOOD MW SEIDLER FJ SLOTKIN TA
Citation
Mw. Wood et al., IMMEDIATE DECLINE IN DNA-SYNTHESIS IN NEONATAL RAT LUNG CAUSED BY EXPOSURE TO 100-PERCENT OXYGEN, Research communications in chemical pathology and pharmacology, 80(3), 1993, pp. 323-328
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in chemical pathology and pharmacology → ACNP
ISSN journal
00345164
Volume
80
Issue
3
Year of publication
1993
Pages
323 - 328
Database
ISI
SICI code
0034-5164(1993)80:3<323:IDIDIN>2.0.ZU;2-M
Abstract
Oxygen therapy in preterm infants is associated with bronchopulmonary dysplasia, but the relative importance of oxygen toxicity as compared to adverse effects of intubation and mechanical ventilation, remains u ncertain. In freely-breathing neonatal rats, exposure to 100% oxygen f or as little as 2 hr produced a significant reduction in lung DNA synt hesis, evaluated by [H-3]thymidine incorporation, without a concomitan t effect on [H-3]leucine incorporation into protein. These results ind icate that hyperoxia has a selective deleterious effect on mitosis in developing lung.