Rk. Agapova et al., THE POSSIBILITY OF DETERMINATION THE GENE TIC HOMEOSTASIS IN HUMAN-POPULATION USING THE COMPLEX OF GENE MARKERS, Genetika, 29(5), 1993, pp. 825-836
The information that we have about functional connection of different
phenotypes of independent loci served for identification of their reci
procal behavior in cohorts differed in healthy status from the same po
pulation. Coefficients of correlation were computed between phenotypes
according to the scheme: everyone with all in a Buryat, on the basis
of the distribution of 17 genetic loci. Their space was transformed to
a standardized one of eigenvectors. Calculation of the distances betw
een genotypes was performed using the Euclidean formula. The same dist
ances were estimated using an alternative formula of reverse cosine fr
om correlation. It was determined: 1) subgroups of ecological risk and
adaptive norm have peculiarities of phenotypical combinations; 2) the
number of reliable correlations between phenotypes 2.5 times exceeded
that in the adaptive part of the population as compared with unfavour
able cohort (according to the health status); 3) the proportion of att
ractably connected phenotypes (the effect of their interaction) was hi
gher than the corresponding repulsive connected ones (the effect of th
eir repulsion) in the adaptive standard subgroup; 4) on the contrary,
the proportion of repulsively connected phenotypes prevailed over the
corresponding attractably associated ones in the ecological risk subgr
oup; 5) there were smaller genetic distances between phenotypes in the
adaptive norm subgroup as compared with those in the ecological risk
cohort. All these data permit to narrate about considerably greater fu
nctional balance of the studied portion of the genome in the clinicall
y healthy subgroups that express the display of genetic homeostasis in
complex discrete nonlinked characters. Interloci correlation between
Hp and Cerumen systems in the three populations studied were obtained.