THE POSSIBILITY OF DETERMINATION THE GENE TIC HOMEOSTASIS IN HUMAN-POPULATION USING THE COMPLEX OF GENE MARKERS

The information that we have about functional connection of different phenotypes of independent loci served for identification of their reci procal behavior in cohorts differed in healthy status from the same po pulation. Coefficients of correlation were computed between phenotypes according to the scheme: everyone with all in a Buryat, on the basis of the distribution of 17 genetic loci. Their space was transformed to a standardized one of eigenvectors. Calculation of the distances betw een genotypes was performed using the Euclidean formula. The same dist ances were estimated using an alternative formula of reverse cosine fr om correlation. It was determined: 1) subgroups of ecological risk and adaptive norm have peculiarities of phenotypical combinations; 2) the number of reliable correlations between phenotypes 2.5 times exceeded that in the adaptive part of the population as compared with unfavour able cohort (according to the health status); 3) the proportion of att ractably connected phenotypes (the effect of their interaction) was hi gher than the corresponding repulsive connected ones (the effect of th eir repulsion) in the adaptive standard subgroup; 4) on the contrary, the proportion of repulsively connected phenotypes prevailed over the corresponding attractably associated ones in the ecological risk subgr oup; 5) there were smaller genetic distances between phenotypes in the adaptive norm subgroup as compared with those in the ecological risk cohort. All these data permit to narrate about considerably greater fu nctional balance of the studied portion of the genome in the clinicall y healthy subgroups that express the display of genetic homeostasis in complex discrete nonlinked characters. Interloci correlation between Hp and Cerumen systems in the three populations studied were obtained.