Ln. Mkrtchian et Ak. Nersessian, THE INFLUENCE OF MICE IMMUNIZATION WITH H UMAN UMBILICAL-CORD EXTRACTON MICRONUCKEI INDUCTION BY CYCLOPHOSPHAMIDE, Genetika, 29(5), 1993, pp. 866-868
The influence of human umbilical cord extract (HUGE) on mutagenesis in
duces by cyclophosphamide in mice bone marrow cells was studied. It wa
s shown that HUGE had no clastogenic property and decreased significan
tly the number of micronuclei in bone marrow cells of mice during 5 da
ys after the last HUGE infection. We suppose that the antimutagenic ef
fect is connected with interferon induction by HUGE.