R. Prado et al., EFFECTS OF NITRIC-OXIDE SYNTHASE INHIBITION ON CEREBRAL BLOOD-FLOW FOLLOWING BILATERAL CAROTID-ARTERY OCCLUSION AND RECIRCULATION IN THE RAT, Journal of cerebral blood flow and metabolism, 13(4), 1993, pp. 720-723
The effects of bilateral carotid artery occlusion/recirculation on cor
tical CBF (cCBF) were studied in rats following the intravenous admini
stration of either the nitric oxide synthase inhibitor N(G)-nitro-L-ar
ginine methyl ester hydrochloride (L-NAME; 30 mg/kg) or an equivalent
volume of saline (500 mul). Induction of bilateral carotid occlusion (
BCO) in L-NAME-treated animals resulted in a reduction of cCBF to 30%
of baseline. During recirculation subsequent to 20 min of BCO, cCBF in
L-NAME-infused animals remained at 30% of baseline. In contrast, cCBF
in saline-treated control animals returned to the original baseline l
evel following a similar reduction to 30-40% of baseline during BCO. T
hese results indicate that inhibition of nitric oxide generation limit
s normalization of regional cortical perfusion following occlusion of
proximal large cerebral vessels.