BIODEGRADABLE DELIVERY SYSTEM FOR SINGLE-STEP IMMUNIZATION WITH TETANUS TOXOID

Authors
RAGHUVANSHI RS SINGH M TALWAR GP
Citation
Rs. Raghuvanshi et al., BIODEGRADABLE DELIVERY SYSTEM FOR SINGLE-STEP IMMUNIZATION WITH TETANUS TOXOID, International journal of pharmaceutics, 93(1-3), 1993, pp. 180000001-180000005
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
93
Issue
1-3
Year of publication
1993
Pages
180000001 - 180000005
Database
ISI
SICI code
0378-5173(1993)93:1-3<180000001:BDSFSI>2.0.ZU;2-A
Abstract
Tetanus toxoid (TT) loaded biodegradable microspheres were prepared fr om poly(DL-lactide-co-glycolide) (monomer ratio 65:35) of Mol. Wt 7500 0. The method of preparation was emulsification-solvent evaporation. I n vitro vaccine release data are discussed. An in vivo immune response study was performed on rats. Results of immunization with the convent ional schedule of TT and encapsulated TT until 5 months after immuniza tion are presented, which were found to be comparable.