STAUROSPORINE BLOCKS THE RECEPTOR-DEPENDE NT ACTIVATION OF NA+ H+ EXCHANGER/

Authors
NIKIFOROV EL TREPAKOVA ES ZINCHENKO VP
Citation
El. Nikiforov et al., STAUROSPORINE BLOCKS THE RECEPTOR-DEPENDE NT ACTIVATION OF NA+ H+ EXCHANGER/, Biologiceskie membrany, 9(10-11), 1992, pp. 1039-1042
Citations number
17
Categorie Soggetti
Cytology & Histology
Journal title
Biologiceskie membrany → ACNP
ISSN journal
02334755
Volume
9
Issue
10-11
Year of publication
1992
Pages
1039 - 1042
Database
ISI
SICI code
0233-4755(1992)9:10-11<1039:SBTRNA>2.0.ZU;2-I
Abstract
The role of protein kinase C (PKC) in receptor-dependent regulation of Na+/H+ exchanger was investigated in rat thymocytes and Ehrlich ascit es tumor cells (EATC). It was shown that receptor-dependent activation of Na+/H+ exchanger as well as induction of plasma membrane Ca2+ perm eability in thymocyte, are under the PKC control. By contrast, in EATC the stimulus-induced pH(i) rise is due to PKC/phospholipase C-indepen dent mechanisms. The contribution of the tyrosine-specific protein kin ase in the Na+/H+ exchanger activation in EATC is proposed.