MODULATORY EFFECT OF DALARGIN ON GLUTAMAT ERGIC SYNAPTIC TRANSMISSIONIN THE AMPULLAE OF LORENZINI OF SKATES

Authors
ANDRIANOV GN AKOEV GN BRAUN HA RYZHOVA IV FOIGT K SHERMAN NO
Citation
Gn. Andrianov et al., MODULATORY EFFECT OF DALARGIN ON GLUTAMAT ERGIC SYNAPTIC TRANSMISSIONIN THE AMPULLAE OF LORENZINI OF SKATES, Biologiceskie membrany, 9(10-11), 1992, pp. 1126-1127
Citations number
2
Categorie Soggetti
Cytology & Histology
Journal title
Biologiceskie membrany → ACNP
ISSN journal
02334755
Volume
9
Issue
10-11
Year of publication
1992
Pages
1126 - 1127
Database
ISI
SICI code
0233-4755(1992)9:10-11<1126:MEODOG>2.0.ZU;2-B
Abstract
The effect of bath-applied synthetic analog of leuenkephaline delargin and its antagonist naloxone on synaptic transmission was studied in a n isolated preparation of the mandibular group of the ampullae of Lore nzinin of skates, Raja clavata. Dalargin (10(-6)-10(-10) mol/l) was sh own to inhibit both the resting and evoked activity in a dose-dependen t manner. Naloxone also inhibited the afferent activity and blocked re sponses elicited by application of dalargin. Excitatory responses to L -glutamate were reduced in the presence of dalargin. It is supposed th at the modulatory effect of dalargin on glutamatergic synaptic transmi ssion in the ampullae of Lorenzini acts via specific opiate receptors.