INTERFERON-ALPHA-II ACTION OF SODIUM-CHAN NELS IN HUMAN NEUROBLASTOMAIMR-32 CELLS

Authors
VIATCHENKOKARPINSKI SV POGORELAJA NH MAGURA IS ROZHMANOVA OM MATZUKA GH SENIUK OF
Citation
Sv. Viatchenkokarpinski et al., INTERFERON-ALPHA-II ACTION OF SODIUM-CHAN NELS IN HUMAN NEUROBLASTOMAIMR-32 CELLS, Biologiceskie membrany, 9(10-11), 1992, pp. 1159-1160
Citations number
3
Categorie Soggetti
Cytology & Histology
Journal title
Biologiceskie membrany → ACNP
ISSN journal
02334755
Volume
9
Issue
10-11
Year of publication
1992
Pages
1159 - 1160
Database
ISI
SICI code
0233-4755(1992)9:10-11<1159:IAOSNI>2.0.ZU;2-2
Abstract
It was shown that human interferon alphaII modulates sodium current in human neuroblastoma cells by changing the kinetic parameters of fast sodium current. The maximum effect was observed 5-10 min after interfe ron application. The action of 2'-5'-oligoadenylate on sodium current is identical to that of interferon alphaII. The effect of 2'-5'-oligoa denylate is enhanced as its concentration in pipette solution rises. T he same effect of 2'-5'-oligoadenylate was demonstrated in mouse neuro blastoma N1E-115 cells.