INTRACELLULAR PH OSCILLATIONS AND PH-DIST RIBUTION PATTERN OF IMMUNOCOMPETENT CELL-POPULATION

Experimental measurements of intracellular pH kinetics detect intracel lular pH (pH(in)) rhythms with a period about an hour and an amplitude comparable with the standard deviation of pH(in) in cell population. It was shown that pH(in) oscillations were probably to affect the expe rimental pH-distribution pattern. The pH-distribution of the populatio n at normal physiological state is usually close to the normal pattern . The time-course of the pH(in) value for the cell population was show n to have a pattern of a kind of beatings to get the normal pH-distrib ution. Distributions of several <<beating>> - functions were used to a pproximate an experimental pH-distribution of immunocompetent cell pop ulation.