IN-VITRO BIOADHESION OF A BUCCAL, MICONAZOLE SLOW-RELEASE TABLET

The bioadhesive characteristics of thermally modified starch/polyacryl ic acid (PAA) tablets, containing miconazole nitrate, were determined. The detachment force and work of adhesion were significantly affected by the ratio of drum-dried waxy maize starch and PAA. Pure PAA showed the highest detachment force and work of adhesion while the lowest fo rce and work of adhesion were observed for pure starch. There was a pr onounced effect of molecular weight of PAA on the bioadhesive characte ristics. Miconazole nitrate did not influence bioadhesion up to a conc entration of 30%. The influence of additives was negligible and fluctu ations of pH did not influence the bioadhesive strength of the tablet.