AGE-DEPENDENT DECREASE OF SYNAPTIC PLASTICITY IN THE NEOCORTEX OF ALPHA-CAMKII MUTANT MICE

Authors
KIRKWOOD A SILVA A BEAR MF
Citation
A. Kirkwood et al., AGE-DEPENDENT DECREASE OF SYNAPTIC PLASTICITY IN THE NEOCORTEX OF ALPHA-CAMKII MUTANT MICE, Proceedings of the National Academy of Sciences of the United Statesof America, 94(7), 1997, pp. 3380-3383
Citations number
21
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
94
Issue
7
Year of publication
1997
Pages
3380 - 3383
Database
ISI
SICI code
0027-8424(1997)94:7<3380:ADOSPI>2.0.ZU;2-Q
Abstract
Synaptic long-term potentiation (LTP) and long-term depression (LTD) w ere studied in the visual cortex of mutant mice lacking alpha-calcium/ calmodulin-dependent protein kinase II (alpha CaMKII). In adult mutant s, little LTD or LTP could be elicited using standard conditioning pro tocols, However, substantial LTD and LTP were induced In 4- to 5-week- old mutants, Thus, the reduction in cortical plasticity in alpha CaMKI I (-/-) mice is conditional, with the relevant condition being postnat al age.