CEREBRAL VASOCONSTRICTOR MEDIATORS

Endogenous cerebral vasoconstrictor mediators regulate vascular resist ance and blood flow in the brain as a whole and in various regions and participate in the pathogenesis of cerebral circulatory disturbances. Vasoconstrictors are effective in the treatment of diseases associate d with cerebral vasodilatation. There are variations in the response o f cerebral arteries from primate and subprimate mammals; therefore, in formation as to similarities and differences in their response is quit e important in evaluating the physiological role, involvement in patho genesis and therapeutic usefulness of the mediators in healthy men and patients. In this review we described characteristics of the action o f vasoconstrictors (amines, peptides, prostanoids, and others) on isol ated cerebral arteries from mammals, including humans and monkeys.