CEREBRAL-CIRCULATION DURING DIABETES-MELLITUS

Diabetes mellitus is characterized by hyperglycemia, a decrease in cir culating insulin and the development of macro- and microvascular patho logy. Hyperglycemia appears to be a primary determinant for the struct ural, biochemical and functional changes that occur in large and small blood vessels during diabetes mellitus. While much research has focus ed on the effects of diabetes mellitus on the peripheral circulation, it is clear that diabetes mellitus also has profound effects on the ce rebral circulation. Thus, the focus of this review is to discuss morph ological and functional alterations in the cerebral circulation during diabetes mellitus.