INFLUENCE OF CHRONIC INTOXICATION WITH SELENIUM ON COLLAGEN AND ELASTIN CONTENT IN TISSUES OF RAT

Authors
KUCHARZ EJ OLCZYK K
Citation
Ej. Kucharz et K. Olczyk, INFLUENCE OF CHRONIC INTOXICATION WITH SELENIUM ON COLLAGEN AND ELASTIN CONTENT IN TISSUES OF RAT, Toxicology letters, 68(3), 1993, pp. 295-299
Citations number
16
Categorie Soggetti
Toxicology
Journal title
Toxicology letters → ACNP
ISSN journal
03784274
Volume
68
Issue
3
Year of publication
1993
Pages
295 - 299
Database
ISI
SICI code
0378-4274(1993)68:3<295:IOCIWS>2.0.ZU;2-C
Abstract
Rats were intoxicated with sodium selenite (0.3 mg/kg body wt.) for 10 weeks. An increase in total collagen content in skin and a decrease i n the lungs, liver and kidneys were observed. Enhanced serum and urine levels of collagen metabolites were found. Elastin content was shown to be increased in the lung, liver, heart muscle and kidney of seleniu m-intoxicated rats.