Ra. Silvestre et al., REVERSAL OF THE INHIBITORY EFFECTS OF CALCITONIN-GENE-RELATED PEPTIDE(CGRP) AND AMYLIN ON INSULIN-SECRETION BY THE 8-37-FRAGMENT OF HUMAN CGRP, Biochemical pharmacology, 45(11), 1993, pp. 2343-2347
The 8-37 fragment of human calcitonin gene-related peptide [(8-37)hCGR
P] antagonizes the effects of calcitonin gene-related peptide (CGRP) a
nd amylin in a number of tissues. We have studied the influence of (8-
37)hCGRP on the effects of both CGRP and amylin on insulin secretion.
In the perfused rat pancreas, homologous CGRP and amylin, at 75 pM, ex
erted comparable inhibitory effects on the insulin response to 9 mM gl
ucose (ca. 70%; P < 0.025). These effects were antagonized by (8-37)hC
GRP (1 muM). Our results suggest that CGRP and amylin act on the B-cel
l, at least in part, through a common receptor.