GLUCOCORTICOID MODULATION OF NEUROTROPHIN EXPRESSION IN IMMORTALIZED MOUSE HIPPOCAMPAL-NEURONS

Authors
Citation
Jl. Scully et U. Otten, GLUCOCORTICOID MODULATION OF NEUROTROPHIN EXPRESSION IN IMMORTALIZED MOUSE HIPPOCAMPAL-NEURONS, Neuroscience letters, 155(1), 1993, pp. 11-14
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
03043940
Volume
155
Issue
1
Year of publication
1993
Pages
11 - 14
Database
ISI
SICI code
0304-3940(1993)155:1<11:GMONEI>2.0.ZU;2-O
Abstract
To see whether glucocorticoid hormones can influence the regulation of neurotrophin expression in hippocampal neurons, we have used reverse- transcription followed by polymerase chain reaction to investigate cha nges in the mRNA levels of nerve growth factor (NGF) and neurotrophin- 3 (NT-3) in immortalized hippocampal neurons after dexamethasone appli cation. Our results show that NGF mRNA levels rise in both embryonic a nd postnatal neurons, but with different time courses, while NT-3 leve ls rise in the embryonic but not in the postnatally derived cell line. Modulation of NT expression by glucocorticoids may therefore be devel opmentally regulated.