MUTANT MOUSE CEREBELLUM DOES NOT PROVIDE SPECIFIC SIGNALS FOR THE SELECTIVE MIGRATION AND DEVELOPMENT OF TRANSPLANTED PURKINJE-CELLS

Embryonic cerebellum transplanted to adult Purkinje cell degenerate mi ce was assessed for integration and Purkinje cell migration by using t he antigenic markers Thy-1 and Leu-4. It was found that the grafted ce lls migrated into the host's molecular layer, but there was no evidenc e for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with othe r grafted cells and not with the host's cells.