EARLY AND TRANSIENT EFFECTS OF NEUTRON-IRRADIATION ON DOPAMINE-RECEPTORS IN THE ADULT-RAT BRAIN

Authors
MARTIN C RUBIO I FATOME M
Citation
C. Martin et al., EARLY AND TRANSIENT EFFECTS OF NEUTRON-IRRADIATION ON DOPAMINE-RECEPTORS IN THE ADULT-RAT BRAIN, Neuroscience letters, 155(1), 1993, pp. 77-80
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
155
Issue
1
Year of publication
1993
Pages
77 - 80
Database
ISI
SICI code
0304-3940(1993)155:1<77:EATEON>2.0.ZU;2-Z
Abstract
The early neurochemical effects of neutron-gamma radiation exposures w ere studied through ligand dopamine D1, D2 receptors binding experimen ts. The parameters of binding were investigated on crude preparations from striatum at different delays (from 2 to 72 hours) after irradiati on. An early and transient increase in the total number of sites was s een after exposure, even at infra-lethal dose. This 'radiosensitivity' was higher for D1 than for D2 receptor. It is assumed that these modi fications could participate in the early neuro-vegetative syndrome obs erved in irradiated persons.