COMPARATIVE TRIAL OF CLOMIPHENE CITRATE HUMAN MENOPAUSAL GONADOTROPINAND THE CONTRACEPTIVE PILL, FOLLOWED BY CLOMIPHENE CITRATE HUMAN MENOPAUSAL GONADOTROPIN, IN A GAMETE INTRAFALLOPIAN TRANSFER PROGRAM

Purpose: It may sometimes be necessary to regulate cycles in assisted reproduction. Cycles can be regulated with gonadotropin releasing horm one (GnRHa) agonist but other methods can also be used. The aim of thi s study was to compare the pregnancy rate in a gamete intrafallopian t ransfer (GIFT) program in patients receiving a contraceptive pill/Clom id/human menopausal gonadotropin (hMG) regimen (study group), with the standard Clomid/hMG regime (control group). Fifty one patients in the study group were carefully matched for patient age, infertility diagn osis (female), semen parameters, number of follicles, and number of oo cytes transferred into consideration with a control group. Results: Th e overall pregnancy rate was 21.6% (11/51) in the study group and 47% (24/51) in the control group (P = 0.01). However, the ongoing pregnanc y rate in the two groups did not differ significantly, 11.8% (6/51) vs 27.5% (14/51) (P = 0.08). In the study group, 7.8% of patients had to be seen over a weekend, compared to 13.7% in the control group (not s ignificant). Conclusion: From the findings we conclude that, although this method of controlling cycles can be useful in selected patients, it is not the ultimate method.